B. breve MCC1274

Clinical Efficacy

MCC1274: Memory Bifidobacterium

MCC1274 improves cognitive function in people with mild cognitive impairment

Changes in cognitive function after intake of MCC1274
Kobayashi et al. The Journal of Prevention of Alzheimer's Disease. 2018

In a preliminary study, elderly subjects with a high possibility of mild cognitive impairment (MCI) were asked to take Bifidobacterium breve MCC1274 (20 billion CFU/day), and changes were verified by a cognitive function evaluation test (Mini-Mental State Exam: MMSE). As a result, a significant increase in cognitive function was observed after 16 and 24 weeks of intake.

An RCT study confirmed that MCC1274 helps to maintain memory, a part of cognitive function

Actual value of cognitive function test (RBANS score)
Xiao et al. Journal of Alzheimer's Disease. 2020

Furthermore, we tested changes in cognitive function assessed by RBANS in elderly who were concerned about forgetfulnesssubjects (age: 50-79 years old, subject number: MCC1274 group = 40, Placebo group = 40), after having them take Bifidobacterium breve MCC1274 (20 billion CFU/day). The results showed that the subjects who took Bifidobacterium breve MCC1274 showed significant improvement in immediate memory score, delayed memory score and visuospatial/constructional score in RBANS compared to the placebo group.